Biological samples represent formidable challenges in sample preparation that hold important consequences for LC analysis. Cleaner samples translate to more robust, reproducible LC analysis, with fewer repeat runs, and less equipment down time. The challenge is knowing which sample preparation technique to combine with both your sample and LC method.

In this discussion we will look at some common bio sample preparation techniques, from solvent exchanges to solid phase extractions. We will then discuss how to match the sample preparation technique to both your sample and the desired outcome of your chromatography.