Thermal Analysis is a useful tool for investigating pharmaceutical substances for effects such as polymorphism, purity and composition, phase shifts, and stability. The four main techniques of DSC, TGA, TMA, and DMA are ideal for carrying out these investigations over a wide temperature range, from -150 to 1600 °C.

Important Effects and Properties Measured by Thermal Analysis

• DSC: The most important effects that can be analyzed are the melting point, melting range and melting behavior. This technique is also used to determine the heat of fusion, purity, polymorphism, the glass transition, and oxidation stability.
• TOA: Thermo-optical analysis is an auxiliary technique that uses visual observation to study melting behavior and polymorphism.
• TGA: The main applications are investigating evaporation, desorption and vaporization behavior, thermal stability, decomposition kinetics, and composition.
• TMA: Normally used to study the expansion or shrinkage of materials and the glass transition.
• DMA: The most sensitive method for characterizing the glass transition of materials.

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