Determination of Extractable and Leachable Elements Using ICP-MS
E&Ls can enter a drug product during manufacturing, storage, and from the packaging system.
The packaging components (those in contact with the drug product) can contain organic and inorganic E&L contaminants present a risk due to their inherent toxicity, while other compounds may adversely affect the efficacy, stability, and shelf-life of the drug.
We will share an E&L study that shows both the potential for the drug product to become contaminated under extreme conditions (extractables), and the actual contamination that occurs during normal and extended storage (leachables).
Reduction of the Background Level and Compound Carryover for LC/MS Applications
This webinar will focus on two topics for improving results in LC-MS applications. First, the effect of background noise on the overall instrument sensitivity and what can be done to reduce the level of background to improve instrument performance. Second, how to reduce the sample carryover by selecting proper wash solvents and utilizing autosampler capabilities and functions that will result in the reduction of compound carryover.
ICP-MS Tips and Tricks For Tuning and achieving the best Sensitivity and Detection Limits
Join us as we discuss various techniques and provide tips and tricks on achieving the best sensitivity and detection limits on your ICP-MS. We will be covering tuning techniques, nebulizers, lens and other strategies that will ensure your system is performing at its best.
Oligonucleotide Analysis: Practical Techniques and Method Development Optimization for HPLC
Therapeutic oligonucleotides (oligos) have become a focus of interest and promise in biopharmaceutical research due to their potential to treat many kinds of disorders. Whether siRNA, mRNA, or DNA, separating oligos from complex matrix is difficult.
The size, nucleotide complexity, and general variations in these oligos can vary. As a result, liquid chromatography (LC) analysis and purification of oligonucleotides is challenging. We will address chromatographic conditions for oligonucleotide analysis. Specifically, we will discuss fundamental characteristics of the LC column stationary phase, method development guidelines, and optimizations for analytical characterization through scale up to preparative purification.
The Digital Lab Connection | The Lab Central
Is your lab ready to begin its digital transformation?
Using IoT sensor technologies, AI modeling,and advanced analytics, your digital lab can safely capture data, create business intelligence,and implement actioned programs.
Connect your lab digitally by watching this episode of The Lab Central.
Advancing Biopolymer and Synthetic Polymer Analysis: An Introduction to Agilent’s 1260 Infinity II Multi-Angle Light Scattering Detector and WinGPC Software
Multi-angle light scattering (MALS) detection combined with size exclusion chromatography is a powerful technique for the characterization of polymers and biomolecules. MALS detection allows absolute determination of molecular weight and size distribution of biopolymers, such as proteins, and is increasingly used in the biopharmaceutical industry. This presentation will introduce Agilent’s 1260 Infinity II Multi-Angle Light Scattering Detector and features of WinGPC control software. Applications explored include analysis of synthetic polymers, proteins, and AAVs.
New Year resolution for my ICP-MS: I will keep my ICP-MS analysis free from contaminants
While cleaning the ICP-MS routinely can prevent issues, keeping the ICPMS cleaned during the analysis is equally, if not more, important. In this webinar, we will discuss ways to prevent cross contamination and carryover, as well as tips and trick on analyzing.
What to Consider Before Starting Your HPLC Analysis
Having a list of things to consider before starting your HPLC analysis is good practice. It can help you to avoid chromatography problems down the line.
In this webinar, we will discuss:
- Sample: Get to know your target analytes, interferences present in the sample matrix, and how to prepare the sample for HPLC analysis
- Supplies: The importance of using appropriate supplies to get the best results
- Column: How to select the column, equilibrate it, benchmark it with your system, and take care of it
- LC instrument: Getting to know your LC system, the importance of maintaining it, and having a “housekeeping” list for it
Material Characterization by Thermal Analysis
Thermal analysis comprises a group of techniques used to study the relationship between a sample property and its temperature as the sample is heated or cooled in a controlled manner. This includes methods such as differential scanning calorimetry (DSC), thermo-optical analysis (TOA), thermogravimetric analysis (TGA), thermomechanical analysis (TMA), and dynamic mechanical analysis (DMA).
Join the webinar to discover more and get the opportunity to ask our experts your questions!
- Explanation of the basic principles and common uses of thermal analysis (TA)
- Description of different TA techniques and the industries in which they are used
- Insights into which thermal effects can be measured by the different techniques
- Real-life applications for DSC, TOA, TGA, TMA, and DMA
Advancing R&D in the Chemical Industry with PAT
This free online event is for process chemists and engineers who are interested in learning more about the design of safe, robust processes for scale-up. Presenters will share practical examples and case studies that demonstrate benefits including:
- Improved usability and safety
- Enhanced productivity
- Delivery of more information per experiment
- Avoid potential catastrophic events—ensuring the process is operating within safe and optimal conditions
- Prevent waste, lost time and revenue—immediately identify potential issues or deviations from the desired process conditions
- Increase productivity and product quality—facilitating continuous process improvements and optimizations